Certain glycolipid Ags for Vα14i NKT cells can direct the overall cytokine balance of the
immune response. Th2-biasing OCH has a lower TCR avidity than the most potent agonist …

αβ T cell receptor (TCR) recognition of foreign peptides bound to major histocompatibility
complex (pMHC) molecules on the surface of antigen presenting cells is a key event in the …

The T cell receptor (TCR) is one of the most complicated receptors in mammalian cells, and
its triggering mechanism remains mysterious. As an octamer complex, TCR comprises an …

THEMIS, a T cell–specific protein with high expression in CD4+ CD8+ thymocytes, has a
crucial role in positive selection and T cell development. THEMIS lacks defined catalytic …

The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase nonreceptor type 22)
plays a key role in regulating lymphocyte homeostasis, which ensures that the total number …

T cells are key players of the mammalian adaptive immune system. They experience
different mechanical microenvironments during their life cycle, from the thymus, secondary …

More than half of the known protein tyrosine phosphatases (PTPs) in the human genome are
expressed in T cells, and significant progress has been made in elucidating the biology of …

It is well recognized that the composition of the mature T cell population is subject to strict
homeostatic control. The TCR repertoire and relative proportions of various T cell subsets …

Calcineurin is a phosphatase whose primary targets in T cells are NFAT transcription factors,
and inhibition of calcineurin activity by treatment with cyclosporin A (CsA) or FK506 is a …

X-linked lymphoproliferative syndrome, characterized by fatal responses to Epstein-Barr
virus infection, is caused by mutations affecting the adaptor SAP, which links SLAM family …