Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

[HTML][HTML] Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications

F Rong, T Wang, Q Zhou, H Peng, J Yang, Q Fan, P Li - Bioactive Materials, 2023 - Elsevier
Hydrogen sulfide (H 2 S) plays an important role in regulating various pathological
processes such as protecting mammalian cell from harmful injuries, promoting tissue …

Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury

J Li, M Li, L Li, J Ma, C Yao, S Yao - Molecular immunology, 2022 - Elsevier
Sepsis often leads to multiple organ failure or even death and is a significant health problem
that contributes to a heavy economic burden. The lung is the first organ to be affected by …

Gut bacteria signaling to mitochondria in intestinal inflammation and cancer

DN Jackson, AL Theiss - Gut microbes, 2020 - Taylor & Francis
The gastrointestinal microbiome plays a pivotal role in physiological homeostasis of the
intestine as well as in the pathophysiology of diseases including inflammatory bowel …

Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages

J Wu, A Chen, Y Zhou, S Zheng, Y Yang, Y An, K Xu… - Biomaterials, 2019 - Elsevier
Abstract Hydrogen sulfide (H 2 S), as a gaseous messenger, exhibits potential therapeutic
effects in biological and clinical applications. Herein, an in situ forming biomimetic …

The role of hydrogen sulfide in evolution and the evolution of hydrogen sulfide in metabolism and signaling

KR Olson, KD Straub - Physiology, 2016 - journals.physiology.org
The chemical versatility of sulfur and its abundance in the prebiotic Earth as reduced sulfide
(H2S) implicate this molecule in the origin of life 3.8 billion years ago and also as a major …

Small-molecule fluorescent probes for H2S detection: Advances and perspectives

H Li, Y Fang, J Yan, X Ren, C Zheng, B Wu… - TrAC Trends in …, 2021 - Elsevier
Since attributed to the involvement in important physiological and pathological processes,
hydrogen sulfide (H 2 S) is regarded as another gasotransmitter like nitric oxide (NO) and …

Effects of hydrogen sulfide on the microbiome: from toxicity to therapy

AG Buret, T Allain, JP Motta… - Antioxidants & redox …, 2022 - liebertpub.com
Significance: Hydrogen sulfide (H2S), an important regulator of physiology and health, helps
resolve inflammation and promotes tissue repair in the gastrointestinal tract. Recent …

Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production

JP Motta, KL Flannigan, TA Agbor… - Inflammatory bowel …, 2015 - academic.oup.com
Background Microbiota dysbiosis and impaired barrier function are among the most
prominent features of inflammatory bowel disease. In the gastrointestinal tract, hydrogen …