In adolescence, the number of depressive symptoms is rising notably. Individuals may have
relevant depressive symptoms without meeting the full criteria of a major depressive episode …

A vast body of literature has revealed that dysregulation of the hypothalamic–pituitary–
adrenal (HPA) stress axis is associated with etiology of major depressive disorder (MDD) …

Background There is increasing interest in the extent to which individuals with subthreshold
depression face increased risks of subsequent major depression and other disorders …

Background Subthreshold depression is highly prevalent in adolescence, but compared to
major depressive disorder, the clinical impact is under-researched. The aim of this review …

Background Depressive disorders are common in young people and are associated with
significant negative impacts. Newer generation antidepressants, particularly selective …

Background The familial nature of early-onset major depressive disorder (MDD) has been
documented in numerous family studies of adults and is supported by studies of offspring of …

Background Depressive disorders are disabling conditions striking at all ages. In adults,
subthreshold depression (SD) is viewed as being on a continuum with major depressive …

Background: There has been increasing interest in the distinction between subthreshold and
full syndrome disorders and specifically whether subthreshold conditions escalate or predict …

Premorbid affective temperament types have an important role in the clinical evolution of
minor and major mood episodes including the direction of the polarity and the symptom …

Background. In previous studies of subthreshold conditions, co-morbidity has been largely
ignored. The purpose was to examine rates of co-morbidity among subthreshold disorders …