Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Objective To establish in children whether inactivity is the cause of fatness or fatness the
cause of inactivity. Design A non-intervention prospective cohort study examining children …

Background Cross-sectional studies have shown that objectively measured physical activity
is associated with childhood adiposity, and a strong inverse dose–response association with …

Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial
activity,(sub) maximal oxidative phosphorylation capacity (OXPHOS), and mitochondrial …

Mitochondria play a key role in energy metabolism in many tissues, including skeletal
muscle and liver. Inherent disorders of mitochondria such as DNA deletions cause major …

Dietary intake of high-caloric high-fat diets and sedentary lifestyle lead to increased storage
of triglycerides not only in adipose tissue but also ectopically in other tissues. Intracellular …

Multiple organs contribute to the development of peripheral insulin resistance, with the major
contributors being skeletal muscle, liver, and adipose tissue. Because insulin resistance …

Background While an increase in bone marrow adiposity is associated with age-related
bone disease, the function of bone marrow adipocytes has not been studied. The aim of this …