Sialic acids (SA) are a kind of nine-carbon backbone sugars, serving as important molecules
in cell-to-cell or cell-to-extra-cellular matrix interaction mediated by either O-linked …

The structure of a sialoglycan can be translated into to a biological response when it binds to
a specific endogenous lectin. Among endogenous sialic acid-binding lectins in humans are …

Sialic acid-binding receptors are expressed on the surfaces of a variety of immune cells and
have complex and diverse immunoregulatory functions in health and diseases. Recent …

Immune cell-based therapies are a rapidly emerging class of new medicines that directly
treat and prevent targeted cancer. However multiple biological barriers impede the activity of …

Most human Siglecs (sialic acid binding immunoglobulin-like lectins) are expressed on the
surfaces of overlapping subsets of immune cells, and most carry immunoreceptor tyrosine …

Tumor-associated macrophages (TAMs) in the tumor microenvironment potentially enhance
tumor growth and invasion through various mechanisms and are thus an essential factor in …

CD169, also known as Siglec1 or Sialoadhesin (Sn), is a surface adhesion molecule on
human myeloid cells. Being part of the Siglec family, it acts as a receptor for sialylated …

Fcγ receptors (FcγRs) play key roles in the effector function of IgG, but their inappropriate
activation plays a role in several disease etiologies. Therefore, it is critical to better …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is
currently the third leading cause of cancer death. The aggressiveness of PDAC stems from …

Tremendous progress has been seen in the study of the role of sialic acid binding im-
munoglobulin type lectins (Siglecs) in osteoimmunology in the past two decades. Interest in …