Excessive daytime sleepiness (EDS) is a public health issue. However, it remains largely
undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS …

For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterised by an
urge to move the limbs with a circadian pattern (occurring in the evening/at night), more …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

Background The objectives of this review and meta-analysis of polysomnographic data are
those to focus on the clinical use of clonazepam for the management of sleep disorders by …

Although restless legs syndrome (RLS) is a common neurological disorder, it remains poorly
understood from both clinical and pathophysiological perspectives. RLS is classified among …

Summary Restless Legs Syndrome (RLS) is a complex sensorimotor disorder, classified
among the sleep-related movement disorders. Although sensory symptoms appear as key …

Objective Restless legs syndrome (RLS) has serious effects on patients' sleep quality,
physical and mental health. However, the pathophysiological mechanisms of RLS remain …

Sleep is an essential physiological activity, accounting for about one-third of our lives, which
significantly impacts our memory, mood, health, and children's growth. Especially after the …