The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …

Colorectal tumor is a heterogeneous disease, with varying clinical presentation and
prognosis in patients. To establish a platform encompassing this diversity, we generated 55 …

The ligand-stimulated epidermal growth factor receptor (EGFR) has been extensively
studied in the analysis of molecular mechanisms regulating endocytic traffic and the role of …

Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and
growth, and direct cell differentiation, thus playing key roles in normal development and …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The
canonical model of RTK endocytosis involves rapid internalization of an RTK activated by …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as
the internalization of growth factors and receptors, entry of pathogens, and synaptic …