Triptolide and celastrol are predominantly active natural products isolated from the
medicinal plant Tripterygium wilfordii Hook F. These compounds exhibit similar …

Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …

Simple Summary The recovery rate in patients with metastatic colorectal cancer (CRC)
remains low and declines with successive lines of treatment. This phenomenon is caused by …

Celastrol, also named as tripterine, is a pharmacologically active ingredient extracted from
the root of traditional Chinese herb Tripterygium wilfordii Hook F with potent anti …

Abstract AKT/GSK-3β/β-catenin signaling pathway plays an important role in the progression
of colorectal cancer (CRC). Toosendanin (TSN) is a triterpenoid extracted from the bark or …

Ovarian cancer is a gynecological cancer from which it is difficult to be completely cured. It is
common to use regimens as an effective treatment for ovarian cancer, but these inevitably …

Abstract Hypoxia-inducible factor-1 (HIF-1) as a key mediator in tumor metastasis,
angiogenesis and poor patient prognosis, has been recognized as an important cancer drug …

Four series of hypoxia-inducible factor-1 alpha (HIF-1α) functioning derivatives stemming
from modifications to the C-29 carboxyl group of celastrol were designed and synthesized …

Aberrant activation of the Wnt/β-catenin signaling pathway plays a major role in
carcinogenesis and the progression of many malignant tumors, especially gastric cancer …

Wnt/β-catenin and Hippo pathways play essential roles in the tumorigenesis and
development of colorectal cancer. We found that Celastrol, isolated from Tripterygium …