Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's
disease. Under pathological conditions, Tau dissociates from axonal microtubules and …

Transposable elements, known colloquially as 'jumping genes', constitute approximately
45% of the human genome. Cells utilize epigenetic defenses to limit transposable element …

The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark
of tauopathies, including Alzheimer's disease. However, the underlying molecular …

There are currently no disease-modifying therapies for the treatment of tauopathies, a group
of progressive neurodegenerative disorders that are pathologically defined by the presence …

The microtubule-associated protein tau is involved in a number of neurodegenerative
disorders, including Alzheimer's disease. Previous studies have linked oxidative stress and …

Genetics and neuropathology strongly link α-synuclein aggregation and neurotoxicity to the
pathogenesis of Parkinson's disease and related α-synucleinopathies. Here we describe a …

A growing number of studies point to rapamycin as a pharmacological compound that is
able to provide neuroprotection in several experimental models of neurodegenerative …