Therapeutic potential of plant-derived tannins in non-malignant respiratory diseases

S Rajasekaran, N Rajasekar, A Sivanantham - The Journal of Nutritional …, 2021 - Elsevier
Respiratory diseases are the major cause of human illness and death around the world.
Despite advances in detection and treatment, very few classes of safe and effective therapy …

Evolution of natural product scaffolds as potential proteasome inhibitors in developing cancer therapeutics

RH Mir, PA Mir, J Uppal, A Chawla, M Patel, F Bardakci… - Metabolites, 2023 - mdpi.com
Homeostasis between protein synthesis and degradation is a critical biological function
involving a lot of precise and intricate regulatory systems. The ubiquitin-proteasome …

Epigallocatechin-3-Gallate (EGCG), an active compound of green tea attenuates acute lung injury regulating macrophage polarization and Krüpple-like-factor 4 (KLF4 …

SA Almatroodi, A Almatroudi, MA Alsahli, MA Aljasir… - Molecules, 2020 - mdpi.com
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are serious clinical
complications with a high frequency of morbidity and mortality. The initiation and …

The medicinal value of tea drinking in the management of COVID-19

J Ge, T Song, M Li, W Chen, J Li, S Gong, Y Zhao, L Ma… - Heliyon, 2023 - cell.com
Abstract Corona Virus Disease 2019 (COVID-19) is presently the largest international public
health event, individuals infected by the virus not only have symptoms such as fever, dry …

[HTML][HTML] Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis

Q Wang, W Li, H Hu, X Lu, S Qin - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, and can lead to
decreased lung function, respiratory failure and even death. The pathogenesis research and …

(-)-epigallocatechin 3-gallate protects pancreatic β-cell against excessive autophagy-induced injury through promoting FTO degradation

Y Shao, Y Zhang, S Zou, J Wang, X Li, M Qin, L Sun… - Autophagy, 2024 - Taylor & Francis
Excessive macroautophagy/autophagy leads to pancreatic β-cell failure that contributes to
the development of diabetes. Our previous study proved that the occurrence of deleterious …

Natural products are an important source for proteasome regulating agents

P An, LJ Zhang, W Peng, YY Chen, QP Liu, X Luan… - Phytomedicine, 2021 - Elsevier
Background Natural medicines have a long history in the prevention and treatment of
various diseases in East Asian region, especially in China. Modern research has proved that …

Flavor perception and health benefits of tea

J Yu, K Zhang, Y Wang, X Zhai, X Wan - Advances in Food and Nutrition …, 2023 - Elsevier
As one of the most consumed non-alcoholic beverages in the world, tea is acclaimed for its
pleasant flavor and various health benefits. Different types of tea present a distinctive flavor …

Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools

P Moyano, E Sola, MV Naval, L Guerra-Menéndez… - Pharmaceutics, 2023 - mdpi.com
Environmental pollutants'(EPs) amount and diversity have increased in recent years due to
anthropogenic activity. Several neurodegenerative diseases (NDs) are theorized to be …

Epigallocatechine-3-gallate inhibits the adipogenesis of human mesenchymal stem cells via the regulation of protein phosphatase-2A and myosin phosphatase

B Bécsi, Z Kónya, A Boratkó, K Kovács, F Erdődi - Cells, 2022 - mdpi.com
Epigallocatechin-3-gallate (EGCG) has widespread effects on adipocyte development.
However, the molecular mechanisms of EGCG are not fully understood. We investigate the …