The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …
increased prevalence and incidence. In addition to its macrovascular damage, through its …
COVID-19, cytokines, inflammation, and spices: How are they related?
Background Cytokine storm is the exaggerated immune response often observed in viral
infections. It is also intimately linked with the progression of COVID-19 disease as well as …
infections. It is also intimately linked with the progression of COVID-19 disease as well as …
Nrf2 regulation by curcumin: molecular aspects for therapeutic prospects
SH Shahcheraghi, F Salemi, N Peirovi, J Ayatollahi… - Molecules, 2021 - mdpi.com
Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein
(bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 …
(bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 …
Nrf2 modulation in breast cancer
Reactive oxygen species (ROS) are identified to control the expression and activity of
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …
The potential role of curcumin in modulating the master antioxidant pathway in diabetic hypoxia-induced complications
Oxidative stress is the leading player in the onset and development of various diseases. The
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …
Anticancer activity of lactoferrin-coated biosynthesized selenium nanoparticles for combating different human cancer cells via mediating apoptotic effects
EM El‑Fakharany, MM Abu‑Serie, A Ibrahim… - Scientific Reports, 2023 - nature.com
The present study aims to develop a novel nanocombination with high selectivity against
several invasive cancer cells, sparing normal cells and tissues. Bovine lactoferrin (bLF) has …
several invasive cancer cells, sparing normal cells and tissues. Bovine lactoferrin (bLF) has …
A state-of-the-art review on the NRF2 in Hepatitis virus-associated liver cancer
L Kalantari, ZR Ghotbabadi, A Gholipour… - Cell Communication and …, 2023 - Springer
According to a paper released and submitted to WHO by IARC scientists, there would be
905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths …
905,700 new cases of liver cancer diagnosed globally in 2020, with 830,200 deaths …
Inflammaging and brain: Curcumin and its beneficial potential as regulator of microglia activation
Inflammaging is a term used to describe the tight relationship between low-grade chronic
inflammation and aging that occurs during physiological aging in the absence of evident …
inflammation and aging that occurs during physiological aging in the absence of evident …
Modulation of Nrf2/HO-1 by natural compounds in lung cancer
Oxidative stresses (OSs) are considered a pivotal factor in creating various
pathophysiological conditions. Cells have been able to move forward by modulating …
pathophysiological conditions. Cells have been able to move forward by modulating …