Despite comprehensive research efforts over the last decades, the pathomechanisms of age-
related macular degeneration (AMD) remain far from being understood. Large-scale …

The development of more effective targeted therapies for hepatocellular carcinoma (HCC)
patients due to its aggressiveness is urgently needed. DNA methyltransferase inhibitors …

Abstract Deletions, duplications, insertions, inversions, and translocations, collectively called
structural variations (SVs), affect more base pairs of the genome than any other sequence …

The nuclei of multinucleated skeletal muscles experience substantial external force during
development and muscle contraction. Protection from such forces is partly provided by …

With the development of sequencing technology and the dramatic drop in sequencing cost,
the functions of noncoding genes are being characterized in a wide variety of fields (eg …

Linear DNA undergoes a series of compression and folding events, forming various three‐
dimensional (3D) structural units in mammalian cells, including chromosomal territory …

The nucleosome is the fundamental subunit of chromatin. Nucleosome structures are formed
by the combination of histone octamers and genomic DNA. Through a systematic and …

Background This study aimed to explore the expression level and transcriptional regulation
mechanism of Extra Spindle Pole Bodies Like 1 (ESPL1) in bladder cancer (BC). Methods A …

Alzheimer's disease (AD) is a neurodegenerative disease and there is by far no effective
treatment for it, especially in its late stage. Circular RNAs (circRNAs), known as a class of …

The sheer number of gene variants and the extent of the observed clinical and molecular
heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified …