Sympathetic nervous system overactivity and its role in the development of cardiovascular disease

SC Malpas - Physiological reviews, 2010 - journals.physiology.org
This review examines how the sympathetic nervous system plays a major role in the
regulation of cardiovascular function over multiple time scales. This is achieved through …

Evidence for a critical role of the sympathetic nervous system in hypertension

G Grassi, VS Ram - Journal of the American Society of Hypertension, 2016 - Elsevier
Autonomic cardiovascular control is impaired in hypertension, leading to a reduction in the
parasympathetic tone and to an increase in the sympathetic influences to the heart and …

The sympathetic nervous system and blood pressure in humans: implications for hypertension

JP Fisher, JFR Paton - Journal of human hypertension, 2012 - nature.com
A neurogenic component to primary hypertension (hypertension) is now well established.
Along with raised vasomotor tone and increased cardiac output, the chronic activation of the …

Sympathetic nervous activation in obesity and the metabolic syndrome—causes, consequences and therapeutic implications

GW Lambert, NE Straznicky, EA Lambert… - Pharmacology & …, 2010 - Elsevier
The world wide prevalence of obesity and the metabolic syndrome is escalating. Contrary to
earlier experimental evidence, human obesity is characterised by sympathetic nervous …

Impact of type 2 diabetes mellitus on sympathetic neural mechanisms in hypertension

RJ Huggett, EM Scott, SG Gilbey, JB Stoker… - Circulation, 2003 - Am Heart Assoc
Background—Essential hypertension (EHT) is a major cardiovascular risk factor, and the
additional presence of type 2 diabetes mellitus (DM2) increases this risk. However, although …

Sympathetic neural activity in hypertension and related diseases

G Grassi - American journal of hypertension, 2010 - academic.oup.com
Background Several hemodynamic variables, such as blood pressure, vascular resistance,
cardiac output, and heart rate, are regulated, among others, by sympathetic cardiovascular …

Metabolic syndrome: a sympathetic disease?

M Schlaich, N Straznicky, E Lambert… - The lancet Diabetes & …, 2015 - thelancet.com
Metabolic syndrome is associated with adverse health outcomes and is a growing problem
worldwide. Although efforts to harmonise the definition of metabolic syndrome have helped …

Sympathetic neural activation in nondiabetic metabolic syndrome and its further augmentation by hypertension

RJ Huggett, J Burns, AF Mackintosh, DASG Mary - Hypertension, 2004 - Am Heart Assoc
Hypertension is a major cardiovascular risk factor in the metabolic syndrome (MS) in which
the presence of insulin resistance, glucose intolerance, abnormal lipoprotein metabolism …

Neuroinflammation and sympathetic overactivity: Mechanisms and implications in hypertension

D Haspula, MA Clark - Autonomic Neuroscience, 2018 - Elsevier
Essential hypertension is a multifactorial disorder with a strong genetic predisposition.
Although anti-hypertensive medications have drastically reduced cardiovascular diseases …

Aortic pulse wave velocity as a marker of cardiovascular disease in subjects over 70 years old

S Meaume, A Rudnichi, A Lynch, C Bussy… - Journal of …, 2001 - journals.lww.com
Background Aortic pulse wave velocity (PWV) is a significant and independent predictor of
cardiovascular diseases (CVD) in hypertensive subjects and in patients with end-stage renal …