Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system?

L Siddiqi, JA Joles, G Grassi… - Journal of …, 2009 - journals.lww.com
In chronic kidney disease simultaneous activation of the renin–angiotensin and sympathetic
systems occurs. Kidney ischemia seems to play a key role in the pathogenesis. This review …

Neurogenic essential hypertension revisited: the case for increased clinical and research attention

SJ Mann - American Journal of Hypertension, 2003 - academic.oup.com
The management of essential hypertension has increasingly focused on the use of diuretics,
angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers, which lower …

Cardiac autonomic dysfunction in chronic stroke women is attenuated after submaximal exercise test, as evaluated by linear and nonlinear analysis

JV Francica, A Bigongiari, L Mochizuki… - BMC cardiovascular …, 2015 - Springer
Background We evaluated cardiac autonomic modulation in women with chronic ischemic
stroke (at least 4 years post-stroke) at rest and in response to submaximal exercise test …

Sympathetic and baroreflex function in hypertension: implications for current and new drugs

G Grassi - Current pharmaceutical design, 2004 - ingentaconnect.com
The sympathetic nervous system has moved towards center stage in cardiovascular
medicine. The importance of the sympathetic activation in heart failure and in renal …

The role of the kidney and the sympathetic nervous system in hypertension

P Thomas, I Dasgupta - Pediatric nephrology, 2015 - Springer
Nearly one-third of the world's population has hypertension. The human and societal impact
of hypertension is enormous. Primary hypertension accounts for 95% of cases of …

Effects of selective angiotensin II receptor blockade on sympathetic nerve activity in primary hypertensive subjects

J Struck, P Muck, D Trübger, R Handrock… - Journal of …, 2002 - journals.lww.com
Objective The role of the renin–angiotensin system in the regulation of sympathetic nervous
activity in human hypertension was evaluated in patients with moderate primary …

Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome

DA Anichkov, NA Shostak… - Current medical research …, 2005 - Taylor & Francis
Objective: In previous studies, the I1 imidazoline specific agonist rilmenidine effectively
lowered office blood pressure (BP) in patients with metabolic syndrome, improved glucose …

Potential clinical application of recently discovered brain mechanisms involved in hypertension

Y Hirooka, T Kishi, K Ito, K Sunagawa - Hypertension, 2013 - Am Heart Assoc
996 Hypertension December 2013 projections to the paraventricular nucleus (PVN) of the
hypothalamus, the median preoptic nucleus, and the rostral ventrolateral medulla (RVLM) in …

Sympathetic activation secondary to chronic kidney disease: therapeutic target for renal denervation?

E de Beus, R de Jager, JA Joles, G Grassi… - Journal of …, 2014 - journals.lww.com
Percutaneous ablation of the renal nerves [renal denervation (RDN)] has recently become
available for treatment of (therapy-resistant) hypertension. In this review, the potential …

The effect of gender on the sympathetic nerve hyperactivity of essential hypertension

AJ Hogarth, AF Mackintosh, D Mary - Journal of human hypertension, 2007 - nature.com
We planned to determine whether or not there is a difference in the level of muscle
sympathetic nerve activity (MSNA) between hypertensive women and hypertensive men …