Aims To estimate the association of smoking status with rates of (i) infection,(ii)
hospitalization,(iii) disease severity and (iv) mortality from SARS‐CoV‐2/COVID‐19 disease …

The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Summary Background The SARS-CoV-2 delta (B. 1.617. 2) variant was first detected in
England in March, 2021. It has since rapidly become the predominant lineage, owing to high …

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …

Identifying which children and young people (CYP) are most vulnerable to serious infection
due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is important to guide …

Objective To assess the association between learning disability and risk of hospital
admission and death from covid-19 in England among adults and children. Design …

Background The risk of severe COVID-19 outcomes in people with immune-mediated
inflammatory diseases and on immune-modifying drugs might not be fully mediated by …

Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …

Background & Aims The pandemic has resulted in an increase of deaths not directly related
to COVID-19 infection. We aimed to use a national death dataset to determine the impact of …

Background Little is known about the mortality of hospital-acquired (nosocomial) COVID-19
infection globally. We investigated the risk of mortality and critical care admission in …