Uncommon EGFR Compound Mutations in Non-Small Cell Lung Cancer (NSCLC): A Systematic Review of Available Evidence
Compound epidermal growth factor receptor (EGFR) mutations represent a heterogeneous
subgroup of non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations …
subgroup of non-small cell lung cancer (NSCLC) patients with uncommon EGFR mutations …
[HTML][HTML] Amivantamab plus Chemotherapy in NSCLC with EGFR Exon 20 Insertions
C Zhou, KJ Tang, BC Cho, B Liu… - … England Journal of …, 2023 - Mass Medical Soc
Background Amivantamab has been approved for the treatment of patients with advanced
non–small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 …
non–small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 …
Optimizing diagnosis and treatment of EGFR exon 20 insertions mutant NSCLC
F Passiglia, U Malapelle, N Normanno… - Cancer Treatment Reviews, 2022 - Elsevier
The Epidermal growth factor receptor (EGFR) exon (ex) 20 insertions (ins) has been
considered as an “undruggable target” for a long time, with platinum-pemetrexed …
considered as an “undruggable target” for a long time, with platinum-pemetrexed …
Overall survival in advanced epidermal growth factor receptor mutated non-small cell lung cancer using different tyrosine kinase inhibitors in The Netherlands: a …
RGP Gijtenbeek, RAM Damhuis… - The Lancet Regional …, 2023 - thelancet.com
Background Clinical guidelines advise osimertinib as preferred first line treatment for
advanced epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer …
advanced epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer …
Frequency, underdiagnosis, and heterogeneity of epidermal growth factor receptor exon 20 insertion mutations using real‐world genomic datasets
S Viteri, A Minchom, L Bazhenova, SHI Ou… - Molecular …, 2023 - Wiley Online Library
Epidermal growth factor receptor (EGFR) exon 20 insertion mutations (ex20ins) account
for≤ 12% of all EGFR‐mutant nonsmall cell lung cancers. We analysed real‐world datasets …
for≤ 12% of all EGFR‐mutant nonsmall cell lung cancers. We analysed real‐world datasets …
Regulation of signaling from the epidermal growth factor family
AW Burgess - The Journal of Physical Chemistry B, 2022 - ACS Publications
The epidermal growth factor (EGF) system has allowed chemists, biologists, and clinicians to
improve our understanding of cell production and cancer therapy. The discovery of EGF led …
improve our understanding of cell production and cancer therapy. The discovery of EGF led …
Advances in the management of non-small-cell lung cancer harbouring EGFR exon 20 insertion mutations
Epidermal growth factor receptor (EGFR) mutation is one of the key oncogenic mutations in
non-small-cell lung cancer with adenocarcinoma histology. Exon 19 deletions and exon 21 …
non-small-cell lung cancer with adenocarcinoma histology. Exon 19 deletions and exon 21 …
[HTML][HTML] Distribution and detectability of EGFR exon 20 insertion variants in NSCLC
Introduction EGFR exon 20 insertion (ex20ins) mutations represent 5% to 10% of EGFR
mutations in NSCLC. Identifying patients with EGFR ex20ins is challenging owing to the …
mutations in NSCLC. Identifying patients with EGFR ex20ins is challenging owing to the …
Immune checkpoint inhibitors in EGFR-mutant non-small cell lung cancer: A systematic review
Background Since their first introduction in clinical practice, immune checkpoint inhibitors
showed limited benefit in patients with NSCLC harboring EGFR mutations. With the rationale …
showed limited benefit in patients with NSCLC harboring EGFR mutations. With the rationale …
[HTML][HTML] Molecular epidemiology and treatment patterns of patients with EGFR exon 20-mutant NSCLC in the precision oncology era: the European EXOTIC Registry
G Mountzios, D Planchard, G Metro, D Tsiouda… - JTO clinical and …, 2023 - Elsevier
Introduction Real-world evidence regarding molecular epidemiology and management
patterns of patients with EGFR exon-20 mutated, advanced NSCLC outside the context of …
patterns of patients with EGFR exon-20 mutated, advanced NSCLC outside the context of …