We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22
patients with chronic myelogenous leukemia (CML) in chronic, accelerated, or blastic phase …

Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is a member of the
TNF superfamily exerting cytotoxic activities toward tumor cells. Herein, we demonstrate that …

Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment and outcomes of chronic
myeloid leukemia (CML). Despite their significant impact on the management of CML, there …

Disease progression and relapse of chronic myeloid leukemia (CML) are caused by therapy
resistant leukemia stem cells (LSCs), and cure relies on their eradication. The …

This study demonstrates in both stable and inducible BCR-ABL–expressing hematopoietic
cells a down-regulation of the major mammalian DNA repair protein DNA-PKcs by BCR …

Background: Priapism is defined as a penile erection that persists four or more hours and is
unrelated to sexual stimulation. Priapism resulting from hematologic malignancy is most …

Clonality studies of mature cells suggest that the primary transformation event in
myelodysplastic syndrome (MDS) most frequently occurs in a myeloid-restricted progenitor …

Importance of the field: Cytarabine is a polar nucleoside drug used for the treatment of
myeloid leukemia and non-Hodgkin's lymphoma. The drug has a short plasma half-life, low …

Twenty-eight adults with chronic myelogenous leukemia (CML) that had relapsed after
allogeneic stem cell transplantation (SCT) received imatinib mesylate (400-1000 mg/d) …

Purpose Dasatinib is a prototypic short half-life BCR-ABL1 tyrosine kinase inhibitor. The
recommended dose of dasatinib for chronic myeloid leukemia in chronic phase was …