Adenosine A2A receptors, abundantly expressed on striatal medium spiny neurons, appear
to activate signaling cascades implicated in the regulation of coexpressed ionotropic …

Introduction 3. Basic aspects of adenosine as a neuromodulator relevant for cognitive
functions 4. Effects of adenosine receptor antagonists on cognitive deficits in aged rodents …

Sporadic Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most
common neurodegenerative diseases and as such they represent major public health …

Background: The safety and efficacy of istradefylline, a selective adenosine A2A receptor
antagonist, was evaluated in a 12-week, double-blind study in levodopa-treated Parkinson …

Adenosine receptors represent a family of G‐protein coupled receptors that are ubiquitously
expressed in a wide variety of tissues. This family contains four receptor subtypes: A1 and …

Parkinson׳ s disease (PD) is chronic progressive neurodegenerative disorder characterized
by profound loss of dopaminergic neurons in the nigrostriatal pathway. It is recognized by …

The basal ganglia (BG) are involved in motor function, habit formation, and reward or
addictive behaviors, but the question as to how the BG integrate arousal with these …

The classic endogenous somnogen adenosine promotes sleep via A 1 and A 2A receptors.
In this chapter, we present an overview of the current knowledge regarding the regulation of …

Future therapies in Parkinson's disease may substantially build on the existence of intra‐
membrane receptor–receptor interactions in DA receptor containing heteromeric receptor …

Adenosine A 2A receptor antagonism is a new therapeutic strategy in the symptomatic
treatment of Parkinson's disease (PD). This review addresses how adenosine A 2A …