Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A2A receptors in the caudate‐putamen of …
W Hauber, P Neuscheler, J Nagel… - European Journal of …, 2001 - Wiley Online Library
The present study sought to determine, in more detail, the effects of an unselective and a
selective adenosine A2A receptor blockade on catalepsy induced by a blockade of …
selective adenosine A2A receptor blockade on catalepsy induced by a blockade of …
A2A antagonists as novel non-dopaminergic therapy for motor dysfunction in PD
P Jenner - Neurology, 2003 - AAN Enterprises
The future management of Parkinson's disease (PD) requires pharmacologic agents that do
not lose efficacy with disease progression or induce dyskinesia and that are free of other …
not lose efficacy with disease progression or induce dyskinesia and that are free of other …
Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonists
Y Tanimura, S Vaziri, MH Lewis - Behavioural brain research, 2010 - Elsevier
Repetitive behaviors are diagnostic for autism and common in related neurodevelopmental
disorders. Despite their clinical importance, underlying mechanisms associated with the …
disorders. Despite their clinical importance, underlying mechanisms associated with the …
Antidepressant activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002) on learned helplessness in rats
K Yamada, M Kobayashi, S Shiozaki, T Ohta, A Mori… - …, 2014 - Springer
Rationale Istradefylline, an adenosine A 2A receptor antagonist, improves motor function in
animal models of Parkinson's disease (PD) and in patients with PD. In addition, some A 2A …
animal models of Parkinson's disease (PD) and in patients with PD. In addition, some A 2A …
New therapies for the treatment of Parkinson's disease: adenosine A2A receptor antagonists
A Pinna, J Wardas, N Simola, M Morelli - Life sciences, 2005 - Elsevier
The development of non-dopaminergic therapies for the treatment of Parkinson's disease
(PD) has attracted much interest in recent years. Among new different classes of drugs …
(PD) has attracted much interest in recent years. Among new different classes of drugs …
SCH 58261, an A2A adenosine receptor antagonist, counteracts parkinsonian‐like muscle rigidity in rats
J Wardas, J Konieczny, E Lorenc‐Koci - Synapse, 2001 - Wiley Online Library
The aim of the present study was to find out whether blockade of adenosine A2A receptors
by a selective antagonist, SCH 58261, influenced parkinsonian‐like muscle rigidity. Muscle …
by a selective antagonist, SCH 58261, influenced parkinsonian‐like muscle rigidity. Muscle …
Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and …
K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …
Industry forum: Progress in pursuit of therapeutic A2A antagonists: The adenosine A2A receptor selective antagonist KW6002: Research and development toward a …
H Kase - Neurology, 2003 - AAN Enterprises
Research and development of the adenosine A2A receptor selective antagonist KW6002
have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD) …
have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD) …
Targeting adenosine signaling in Parkinson's disease: from pharmacological to non-pharmacological approaches
Parkinson's disease (PD) is one of the most prevalent neurodegenerative disease
displaying negative impacts on both the health and social ability of patients and …
displaying negative impacts on both the health and social ability of patients and …
A high-fat diet impacts memory and gene expression of the head in mated female Drosophila melanogaster
O Rivera, L McHan, B Konadu, S Patel… - Journal of Comparative …, 2019 - Springer
Obesity predisposes humans to a range of life-threatening comorbidities, including type 2
diabetes and cardiovascular disease. Obesity also aggravates neural pathologies, such as …
diabetes and cardiovascular disease. Obesity also aggravates neural pathologies, such as …