Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson's disease: a single-arm, open-label, prospective, multicenter study
M Iijima, S Orimo, H Terashi, M Suzuki… - Expert Opinion on …, 2019 - Taylor & Francis
Background: Gait disorders are common in Parkinson's disease patients who respond
poorly to dopaminergic treatment. Blockade of adenosine A2A receptors is expected to …
poorly to dopaminergic treatment. Blockade of adenosine A2A receptors is expected to …
Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6‐hydroxydopamine rat model of …
A Pinna, S Pontis, F Borsini, M Morelli - Synapse, 2007 - Wiley Online Library
Evidence obtained in rodent and primate models of Parkinson's disease (PD) and
preliminary clinical trials, indicates that adenosine A2A receptor antagonists might represent …
preliminary clinical trials, indicates that adenosine A2A receptor antagonists might represent …
Plastic control of striatal glutamatergic transmission by ensemble actions of several neurotransmitters and targets for drugs of abuse
DM Lovinger, JG Partridge… - Annals of the New York …, 2003 - Wiley Online Library
Long‐lasting alterations in the efficacy of glutamatergic synapses, such as long‐term
potentiation (LTP) and long‐term depression (LTD), are prominent models for mechanisms …
potentiation (LTP) and long‐term depression (LTD), are prominent models for mechanisms …
Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis
S kah Ng, H Higashimori, M Tolman, Y Yang - Experimental neurology, 2015 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease in
which the majority of upper and lower motor neurons are degenerated. Despite intensive …
which the majority of upper and lower motor neurons are degenerated. Despite intensive …
Role of adenosine A2A receptors in motor control: relevance to Parkinson's disease and dyskinesia
Adenosine is an endogenous purine nucleoside that regulates several physiological
functions, at the central and peripheral levels. Besides, adenosine has emerged as a major …
functions, at the central and peripheral levels. Besides, adenosine has emerged as a major …
[HTML][HTML] The challenge of developing adenosine A2A antagonists for Parkinson disease: Istradefylline, preladenant, and tozadenant
Laboratory and clinical experience have pointed to the value of targeting motor pathways
emerging from the striatum to treat problems arising in advanced Parkinson's disease (PD) …
emerging from the striatum to treat problems arising in advanced Parkinson's disease (PD) …
In vitro pharmacological profile of the A2A receptor antagonist istradefylline
M Saki, K Yamada, E Koshimura, K Sasaki… - … archives of pharmacology, 2013 - Springer
Adenosine A 2A receptors are suggested to be a promising non-dopaminergic target for the
treatment of Parkinson's disease (PD). Istradefylline is an adenosine A 2A receptor …
treatment of Parkinson's disease (PD). Istradefylline is an adenosine A 2A receptor …
Compounds specific to adenosine A1 receptors and uses thereof
AL Castelhano, B McKibben, DJ Witter - US Patent 6,680,322, 2004 - Google Patents
Lee T, et al.,(2000)“Protective effects of renal ischemic preconditioning and adenosine
pretreatment: role of A1 and A3 receptors”, Am. J. Physiol. Renal Physiol., 278: F380–F387 …
pretreatment: role of A1 and A3 receptors”, Am. J. Physiol. Renal Physiol., 278: F380–F387 …
Purinergic receptors in basal ganglia diseases: shared molecular mechanisms between Huntington's and Parkinson's disease
Huntington's (HD) and Parkinson's diseases (PD) are neurodegenerative disorders caused
by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to …
by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to …
[HTML][HTML] Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction
Behavioral and molecular characterization of cell-type-specific populations governing fear
learning and behavior is a promising avenue for the rational identification of potential …
learning and behavior is a promising avenue for the rational identification of potential …