Adenosine A2A receptors are found on striatal neurones projecting to the external pallidum.
KW‐6002 (istradefylline) is a potent and selective antagonist for the adenosine A2A …

The adenosine A 2A receptor (A 2A R) is increasingly recognized as a novel therapeutic
target in Parkinson disease. In striatopallidal neurons, the G-protein α olf subtype is required …

We isolated and characterized a 4.8‐kb 5′ flanking region of the rat A2A adenosine
receptor (A2A‐R) gene in the present study. Promoter activity was observed with this DNA …

Improving exercise capacity during adolescence impacts positively on cognitive and motor
functions. However, the neural mechanisms contributing to enhance physical performance …

In the past few years, a number of laboratories have used gene targeting via homologous
recombination to generate mice deficient for key molecules involved in dopaminergic …

To elucidate the genetic influences contributing to susceptibility to seizure disorders,
researchers have long used selected lines and inbred strains of rodents. In recent years, the …

Adenosine A2A antagonists can exert antiparkinsonian effects in animal models. Recent
experiments studied the ability of MSX-3 (an adenosine A2A antagonist) to reverse the …

Adenosine A2A receptors present in the central nervous system have been implicated in the
modulation of motor functions. Accordingly, adenosine A2A receptor antagonists currently …

Forebrain dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation. Adenosine A2A antagonists reverse many of the behavioral effects of DA …

Caffeine is a nonselective competitive blockade of adenosine A1 and A2A receptors. In this
report, we studied the efficacy of 100 mg of caffeine per day on the freezing of gait (FOG) for …