The adenosine A (2A) receptor as an attractive target for Parkinson's disease treatment.
JF Chen - Drug news & perspectives, 2003 - europepmc.org
Long-term L-dopa treatment of Parkinson's disease can lose its effectiveness and cause
development of motor complications such as dyskinesia. Furthermore, L-dopa therapy does …
development of motor complications such as dyskinesia. Furthermore, L-dopa therapy does …
[HTML][HTML] The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells
O Kudlacek, H Just, VM Korkhov, N Vartian… - …, 2003 - nature.com
The adenosine A 2A receptor and the dopamine D 2 receptor are prototypically coupled to G
s and G i/G o, respectively. In striatal intermediate spiny neurons, these receptors are …
s and G i/G o, respectively. In striatal intermediate spiny neurons, these receptors are …
Recent advances in adenosine receptor antagonist research
S Hess - Expert Opinion on Therapeutic Patents, 2001 - Taylor & Francis
Four types of adenosine receptors (ARs) have been identified and designated A1, A2A, A2B
and A3. During the past decades, potent antagonists have been developed for each of these …
and A3. During the past decades, potent antagonists have been developed for each of these …
Striatal adenosine A2A receptor blockade increases extracellular dopamine release following L-DOPA administration in intact and dopamine-denervated rats
K Gołembiowska, A Dziubina - Neuropharmacology, 2004 - Elsevier
The influence of the selective adenosine A2A receptor antagonist ZM 241385 on exogenous
l-DOPA-derived dopamine (DA) release in intact and dopamine-denervated rats was studied …
l-DOPA-derived dopamine (DA) release in intact and dopamine-denervated rats was studied …
Novel 8-(furan-2-yl)-3-substituted thiazolo [5, 4-e][1, 2, 4] triazolo [1, 5-c] pyrimidine-2 (3H)-thione derivatives as potential adenosine A2A receptor antagonists
Novel thiazolotriazolopyrimidine derivatives (23–33) designed as potential adenosine A2A
receptor (A2AR) antagonists were synthesized. Molecular docking studies revealed that all …
receptor (A2AR) antagonists were synthesized. Molecular docking studies revealed that all …
Striatal adenosine A2A receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [18F]-MRS5425
AK Bhattacharjee, L Lang, O Jacobson… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: A2A receptors are expressed in the basal ganglia, specifically in
striatopallidal GABAergic neurons in the striatum (caudate–putamen). This brain region …
striatopallidal GABAergic neurons in the striatum (caudate–putamen). This brain region …
8-(Furan-2-yl)-3-phenethylthiazolo [5, 4-e][1, 2, 4] triazolo [1, 5-c] pyrimidine-2 (3H)-thione as novel, selective and potent adenosine A2A receptor antagonist
Antagonism of the human A 2A receptor has been implicated to alleviate the symptoms
associated with Parkinson's disease. The present finding reveals the potential of PTTP (8 …
associated with Parkinson's disease. The present finding reveals the potential of PTTP (8 …
Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by
abnormal sensations that occur primarily at rest or during sleep, which are alleviated by …
abnormal sensations that occur primarily at rest or during sleep, which are alleviated by …
Selective disruption of dopamine D2-receptors/beta-arrestin2 signaling by mood stabilizers
T Del'Guidice, JM Beaulieu - Journal of Receptors and Signal …, 2015 - Taylor & Francis
Mood stabilizers are a heterogeneous class of drugs having antidepressant and anti-manic
effects in bipolar disorders, depression and schizophrenia. Despite wide clinical …
effects in bipolar disorders, depression and schizophrenia. Despite wide clinical …
Injections of the selective adenosine A2A antagonist MSX-3 into the nucleus accumbens core attenuate the locomotor suppression induced by haloperidol in rats
K Ishiwari, LJ Madson, AM Farrar, SM Mingote… - Behavioural brain …, 2007 - Elsevier
There is considerable evidence of interactions between adenosine A2A receptors and
dopamine D2 receptors in striatal areas, and antagonists of the A2A receptor have been …
dopamine D2 receptors in striatal areas, and antagonists of the A2A receptor have been …