Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …

One of the main research areas in biology from the mid‐1980s through the 1990s was the
elucidation of signaling pathways governing cell responses. These studies brought, among …

Cardiac fibrosis is one of the main characteristics of diabetic cardiomyopathy and manifests
excessive accumulation of extracellular matrix proteins in the heart. Several signaling …

Cysteine residues can undergo multiple posttranslational modifications with diverse
functional consequences, potentially behaving as tunable sensors. The intermediate …

Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular
pressure (IOP) is considered to be a predominant risk factor for primary open angle …

The intestinal epithelial apical junctional complex, which includes tight and adherens
junctions, contributes to the intestinal barrier function via their role in regulating paracellular …

Rho-associated, coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase and found to belong to the AGC family of serine/threonine …

A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …