Scalable production and isolation of extracellular vesicles: available sources and lessons from current industrial bioprocesses

C Paganini, U Capasso Palmiero… - Biotechnology …, 2019 - Wiley Online Library
Potential applications of extracellular vesicles (EVs) are attracting increasing interest in the
fields of medicine, cosmetics, and nutrition. However, the manufacturing of EVs is currently …

Therapeutic Targets of Monoclonal Antibodies Used in the Treatment of Cancer: Current and Emerging

B Effer, I Perez, D Ulloa, C Mayer, F Muñoz, D Bustos… - Biomedicines, 2023 - mdpi.com
Cancer is one of the leading global causes of death and disease, and treatment options are
constantly evolving. In this sense, the use of monoclonal antibodies (mAbs) in …

Two‐fold Bioorthogonal Derivatization by Different Formylglycine‐Generating Enzymes

T Krüger, S Weiland, G Falck, M Gerlach… - Angewandte Chemie …, 2018 - Wiley Online Library
Formylglycine‐generating enzymes are of increasing interest in the field of bioconjugation
chemistry. They catalyze the site‐specific oxidation of a cysteine residue to the aldehyde …

Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of Vibrio cholerae O-Specific Polysaccharide-Specific Monoclonal Antibodies

RC Kauffman, O Adekunle, H Yu, A Cho, LE Nyhoff… - Mbio, 2021 - Am Soc Microbiol
Vibrio cholerae causes the severe diarrheal disease cholera. Clinical disease and current
oral cholera vaccines generate antibody responses associated with protection. Immunity is …

Assessment of functional characterization and comparability of biotherapeutics: a review

R Dash, SK Singh, N Chirmule, AS Rathore - The AAPS Journal, 2022 - Springer
Abstract. The development of monoclonal antibody (mAb) biosimilars is a complex process.
The key to their successful development and commercialization is an in-depth …

Modulation of gonadotropins activity by antibodies

E Kara, L Dupuy, C Bouillon, S Casteret… - Frontiers in …, 2019 - frontiersin.org
Gonadotropins are essential for reproduction control in humans as well as in animals. They
are widely used all over the world for ovarian stimulation in women, spermatogenesis …

Green Biologics: Harnessing the Power of Plants to Produce Pharmaceuticals

G Zahmanova, AAA Aljabali, K Takova… - International Journal of …, 2023 - mdpi.com
Plants are increasingly used for the production of high-quality biological molecules for use
as pharmaceuticals and biomaterials in industry. Plants have proved that they can produce …

Distributed demand-side management for microgrids in modern power system

W Kou, SY Park - Uncertainties in Modern Power Systems, 2021 - Elsevier
This chapter introduces the distributed demand-side management strategies for modern
power system with microgrids (MGs). The first distributed demand response (DR) application …

[PDF][PDF] Rational and model-based characterization of heterologous gene expression in biological systems

BB Gengenbach - 2021 - publications.rwth-aachen.de
Recombinant proteins have been in production since about 40 years and until today have
risen from a niche product to an omnipresent protein technology. Enzymes, antibodies …

Multi-stage aqueous two-phase extraction

E Chandler - 2021 - etheses.whiterose.ac.uk
ATPE is an alternative, cheap and continuous protein purification technique which can
handle large and varying material types as well as achieve high purities and yields. It could …