Objectives: To provide guidance for the management of mood disorders, based on scientific
evidence supplemented by expert clinical consensus and formulate recommendations to …

Fortunate are those who rise out of bed to greet the morning light well rested with the energy
and enthusiasm to drive a productive day. Others, however, depend on hypnotics for sleep …

Light therapy (LT) has been widely used in the treatment of seasonal affective disorder.
Recently some evidence indicated that LT may play a role in bipolar depression, either as …

Postpartum psychosis (PPP) is at once the most dangerous and the least understood of
perinatal psychiatric disorders. It affects 1 to 2 per 1000 women and constitutes a true …

Background Women with bipolar disorder are at high risk of affective psychoses following
childbirth (ie “postpartum psychosis”, PP) and there is a need to identify which factors …

Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most
recent drugs in the antidepressant category. Agomelatine's antidepressant actions are …

Introduction: Disorders of rhythmicity can cause a variety of pathologies and are known to
impair processes involved in metabolism, as well as in cardiovascular disease and cancer …

Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder
arise in part from a malfunction of the circadian system, linking the disease with an abnormal …

Chronobiological therapies for mood disorders include manipulations of the sleep–wake
cycle such as sleep deprivation and sleep phase advance and the controlled exposure to …

Abstract Study Objectives: The nuclear receptor REV-ERBα is a potent, constitutive
transcriptional repressor critical for the regulation of key circadian and metabolic genes …