Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

To mount an immune response, T lymphocytes must successfully search for foreign material
bound to the surface of antigen-presenting cells. How T cells optimize their chances of …

The homeostatic chemokines CCL19 and CCL21 and their common cognate chemokine
receptor CCR7 orchestrate immune cell trafficking by eliciting distinct signaling pathways …

Lymphoid organs are meeting zones where lymphocytes come together and encounter
antigens present in the blood and lymph or as delivered by cells migrating from the draining …

Effective search strategies have evolved in many biological systems, including the immune
system. T cells are key effectors of the immune response, required for clearance of …

Lymph nodes (LNs) are integral sites for the generation of immune tolerance, migration of
CD4+ T cells, and induction of Tregs. Despite the importance of LNs in regulation of …

The conduit network is a hallmark of lymph node microanatomy, but lack of suitable imaging
technology has prevented comprehensive investigation of its topology. We employed an …

Fibroblastic reticular cells (FRC) form the structural backbone of the T cell rich zones in
secondary lymphoid organs (SLO), but also actively influence the adaptive immune …

Calculating the time required for a diffusing object to reach a small target within a larger
domain is a feature of a large class of modeling and simulation efforts in biology. Here, we …