In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches

B Forbes, P Bäckman, D Christopher, M Dolovich… - The AAPS journal, 2015 - Springer
This article is part of a series of reports from the “Orlando Inhalation Conference-Approaches
in International Regulation” which was held in March 2014, and coorganized by the …

Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

JP Williamson, AL James, MJ Phillips… - European …, 2009 - Eur Respiratory Soc
The ability to measure airway dimensions is important for clinicians, interventional
bronchoscopists and researchers in order to accurately quantify structural abnormalities and …

Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower airway

RA McLaughlin, JP Williamson, MJ Phillips… - Optics express, 2008 - opg.optica.org
Endoscopic treatment of lower airway pathologies requires accurate quantification of airway
dimensions. We demonstrate the application of a real-time endoscopic optical coherence …

18F-Fluorodeoxyglucose Positron Emission Tomographic Imaging of Pulmonary Functions, Pathology, and Drug Delivery

MB Dolovich - Proceedings of the American Thoracic Society, 2009 - atsjournals.org
18F-FDG positron emission tomographic (PET) scanning is a major imaging tool widely
used to investigate lung function and lung disease. Tomographic imaging of drug delivered …

Challenges in assessing regional distribution of inhaled drug in the human lungs

S Newman, J Fleming - Expert Opinion on Drug Delivery, 2011 - Taylor & Francis
Introduction: Both the total amount of drug deposited in the lungs (whole lung deposition)
and the amount deposited in different lung regions (regional lung deposition) are potentially …

The development of models for the evaluation of pulmonary drug disposition

X Liu, L Jin, JW Upham, MS Roberts - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: The process of drug disposition in the lung after pulmonary delivery is complex
involving absorptive and non-absorptive mechanisms. The lung has also been suggested to …

Positron Emission Tomography and Computed Tomography versus Positron Emission Tomography–Computed Tomography: Tools for Imaging the Lung

MB Dolovich, DP Schuster - Proceedings of the American Thoracic …, 2007 - atsjournals.org
This article reviews the potential use of positron emission tomography (PET), alone and in
combination with computed tomography, for evaluating the severity of disease in cystic …

Quantitative functional imaging and kinetic studies with high‐Z contrast agents using synchrotron radiation computed tomography

JF Adam, S Bayat, L Porra, H Elleaume… - Clinical and …, 2009 - Wiley Online Library
SUMMARY 1 There is an increasing demand in diagnostic radiology for extracting additional
morphological and functional quantitative parameters from three‐dimensional computed …

Imaging pulmonary drug delivery

SP Newman - … Imaging: Validation from Biodistribution to Sites …, 2013 - Wiley Online Library
Pulmonary delivery mainly involves topical therapy of some pulmonary conditions but also
offers potential for systemic therapy using the lungs as a portal of entry to the body. The most …

Optimisation of inhaled corticosteroid delivery to asthmatic children: integration of in vitro and in vivo methods

C Roller - 2012 - research-repository.uwa.edu.au
Abstract [Truncated abstract] Inhaled corticosteroids (ICS) are the treatment of choice for
asthmatic children with persistent symptoms. The inter-relationships between the particle …