The urogenital tract is a complex environment composed of many different types of epithelial
tissues and innate immune cells that sample the surrounding milieu. As a host-adapted …

▪ Abstract The closely related bacterial pathogens Neisseria gonorrhoeae (gonococci, GC)
and N. meningitidis (meningococci, MC) initiate infection at human mucosal epithelia …

Pili prepared from Neisseria gonorrhoeae contain minor amounts of a 110 kd outer
membrane protein denoted PilC. The corresponding gene exists in two copies, pilC1 and …

Etiology, transmission and protection: Neisseria gonorrhoeae (the gonococcus) is the
etiological agent for the strictly human sexually transmitted disease gonorrhea. Infections …

The relative virulence of isogenic clones of colony type 1 (TI)(piliated) and colony type 4
(T4)(nonpiliated) gonococci was assessed in organ cultures of human fallopian tubes. The …

A randomized, placebo-controlled, double-blind efficacy trial of a purified gonococcal pilus
vaccine composed of a single pilus type was tested in 3123 men and 127 women …

Intragenic recombination between the single complete pilin gene (expression locus) and
multiple, distinct, partial pilin gene copies (silent, storage loci) is thought to account for the …

Gonorrhea may be the most extensively studied infection of the past 20 years. The
gonorrhea epidemic in the United States began in the early 1960s and peaked in 1975 …

Antigenic variation is an effective strategy evolved by pathogenic microbes to avoid immune
destruction. Variable Ags such as the variable major protein of Borrelia hermsii, the variant …

The complete amino acid sequence of pilin from gonococcal strain MS11 and the sequence
of constant and variable regions from strain R10 pilin have been determined in order to …