Treatment landscape of triple-negative breast cancer—expanded options, evolving needs
G Bianchini, C De Angelis, L Licata… - Nature reviews Clinical …, 2022 - nature.com
Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …
Therapeutic targeting of the tumor microenvironment
L Bejarano, MJC Jordāo, JA Joyce - Cancer discovery, 2021 - AACR
Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a
promising approach for cancer treatment in recent years due to the critical roles of the TME …
promising approach for cancer treatment in recent years due to the critical roles of the TME …
[HTML][HTML] Heterogeneity of triple negative breast cancer: Current advances in subtyping and treatment implications
As the field of translational 'omics has progressed, refined classifiers at both genomic and
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …
Oncolytic T-VEC virotherapy plus neoadjuvant chemotherapy in nonmetastatic triple-negative breast cancer: a phase 2 trial
H Soliman, D Hogue, H Han, B Mooney, R Costa… - Nature Medicine, 2023 - nature.com
Talimogene laherparepvec (T-VEC) is an oncolytic virus hypothesized to enhance triple-
negative breast cancer (TNBC) responses to neoadjuvant chemotherapy (NAC). This article …
negative breast cancer (TNBC) responses to neoadjuvant chemotherapy (NAC). This article …
Immunotherapy approaches for breast cancer patients in 2023
Immunotherapy, particularly agents targeting the immunoregulatory PD-1/PD-L1 axis,
harnesses the power of the immune system to treat cancer, with unique potential for a …
harnesses the power of the immune system to treat cancer, with unique potential for a …
[HTML][HTML] Tumor microenvironment in breast cancer—updates on therapeutic implications and pathologic assessment
JJ Li, JY Tsang, GM Tse - Cancers, 2021 - mdpi.com
Simple Summary The tumor microenvironment (TME) in breast cancer plays important roles
in tumor behavior and treatment response, making its pathologic assessment critical for …
in tumor behavior and treatment response, making its pathologic assessment critical for …
Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80
Breast cancer cells must avoid intrinsic and extrinsic cell death to relapse following
chemotherapy. Entering senescence enables survival from mitotic catastrophe, apoptosis …
chemotherapy. Entering senescence enables survival from mitotic catastrophe, apoptosis …
[HTML][HTML] A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer
S Tietscher, J Wagner, T Anzeneder… - Nature …, 2023 - nature.com
Immune checkpoint therapy in breast cancer remains restricted to triple negative patients,
and long-term clinical benefit is rare. The primary aim of immune checkpoint blockade is to …
and long-term clinical benefit is rare. The primary aim of immune checkpoint blockade is to …
Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion
Q Zeng, S Saghafinia, A Chryplewicz, N Fournier… - Science, 2022 - science.org
Many human cancers manifest the capability to circumvent attack by the adaptive immune
system. In this work, we identified a component of immune evasion that involves frequent up …
system. In this work, we identified a component of immune evasion that involves frequent up …
Surgery-mediated tumor-promoting effects on the immune microenvironment
Surgical resection continues to be the mainstay treatment for solid cancers even though
chemotherapy and immunotherapy have significantly improved patient overall survival and …
chemotherapy and immunotherapy have significantly improved patient overall survival and …