Preclinical studies coupled with clinical pharmacologic and neuroimaging investigations
have advanced our understanding of brain circuits that modulate pain. Descending pain …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

It has long been appreciated that the experience of pain is highly variable between
individuals. Pain results from activation of sensory receptors specialized to detect actual or …

Chronic pain is a major challenge to clinical practice and basic science. The peripheral and
central neural networks that mediate nociception show extensive plasticity in pathological …

Spinal sensory transmission is under descending biphasic modulation, and descending
facilitation is believed to contribute to chronic pain. Descending modulation from the …

Although placebos have long been considered a nuisance in clinical research, today they
represent an active and productive field of research and, because of the involvement of …

Objectives Osteoarthritis (OA) is the leading cause of musculoskeletal pain and functional
disability worldwide, affecting a growing number of individuals in the western society …

Based on theoretical considerations and recent observations, we argue that continued
suffering of chronic pain is critically dependent on the state of motivational and emotional …

Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …

Neuropathic pain has been described as the “most terrible of all tortures which a nerve
wound may inflict” and arises as a consequence of nerve injury either of the peripheral or …