Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date

WM Oo, C Little, V Duong, DJ Hunter - Drug Design, Development …, 2021 - Taylor & Francis
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum

N Fine, S Lively, CA Séguin, AV Perruccio… - Nature Reviews …, 2023 - nature.com
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the
spine are biomechanically interdependent, typically occur in tandem, and have considerable …

Yoga treatment for chronic non‐specific low back pain

LS Wieland, N Skoetz, K Pilkington… - Cochrane Database …, 2017 - cochranelibrary.com
Background Non‐specific low back pain is a common, potentially disabling condition usually
treated with self‐care and non‐prescription medication. For chronic low back pain, current …

Yoga for chronic non‐specific low back pain

LS Wieland, N Skoetz, K Pilkington… - Cochrane Database …, 2022 - cochranelibrary.com
Background Non‐specific low back pain is a common, potentially disabling condition usually
treated with self‐care and non‐prescription medication. For chronic low back pain, current …

Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis

H Jiang, Q Lu, J Xu, G Huo, Y Cai, S Geng, H Xu… - Scientific Reports, 2023 - nature.com
Studies have found that neutrophil extracellular traps (NETs) which are the specific dying
form of neutrophil upon activation have fundamental role in the rheumatoid arthritis onset …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Chronic pain in musculoskeletal diseases: Do you know your enemy?

R Bonanni, I Cariati, V Tancredi, R Iundusi… - Journal of Clinical …, 2022 - mdpi.com
Musculoskeletal pain is a condition that characterises several diseases and represents a
constantly growing issue with enormous socio-economic burdens, highlighting the …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Direct cost of illness for spinal cord injury: a systematic review

H Malekzadeh, M Golpayegani, Z Ghodsi… - Global spine …, 2022 - journals.sagepub.com
Study Design: Systematic review. Objective: Providing a comprehensive review of spinal
cord injury cost of illness studies to assist health-service planning. Methods: We conducted a …