(1) Background: The developmental origins of health and disease (DOHaD) hypothesis links
adverse fetal exposures with developmental mal-adaptations and morbidity later in life …

Background Gestational sleep apnea is a hypoxic sleep disorder that affects 8–26% of
pregnancies and increases the risk for central nervous system dysfunction in offspring …

Maternal hematological disorders during pregnancy may pose a risk to the neurological
development of newborns. To investigate the association between maternal hematological …

Perinatal hypoxia is a major cause of neurodevelopmental impairment and subsequent
motor and cognitive dysfunctions; it is associated with fetal growth restriction and …

BACKGROUND It is not known whether human fetal brain endothelial cells that form the
blood-brain barrier express angiotensin-converting enzyme 2, transmembrane serine …

Background Fetal hypoxia causes vital, systemic, developmental malformations in the fetus,
particularly in the brain, and increases the risk of diseases in later life. We previously …

Complex congenital heart disease (CCHD) is associated with impaired neurodevelopmental
outcomes. Peri-and post-operative factors are known contributors while the impact of the …

Prenatal hypoxia (PH) is one of the most common adverse stimulation during pregnancy.
The brain is fragile in the fetal period and sensitive to hypoxia. The offspring who have …

Neonatal hypoxia has a negative impact on the developing brain during the sensitive period.
Inflammation plays a key role in the physiological response to hypoxic stress. Considering …

Introduction: Many socially significant diseases are associated with prenatal developmental
disorders. Previously, we showed the pathological role of hypoxia-inducible factor-1 (HIF1) …