Preclinical drug screens are not based on human physiology, possibly complicating
predictions on cardiotoxicity. Drug screening can be humanised with in vitro assays using …

Decades of progress in developmental cardiology has advanced our understanding of the
early aspects of heart development, including cardiomyocyte (CM) differentiation. However …

The inward rectifier potassium current (I K1) is generally thought to suppress cardiac
automaticity by hyperpolarizing membrane potential (MP). We recently observed that I K1 …

Diabetes is an independent risk factor for sudden cardiac death and ventricular arrhythmia
complications of acute coronary syndrome. Prolongation of the QT interval on the …

An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is
the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive …

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently,
novel therapies are being developed. Ultimately, the impact of compounds on the action …

The aim of this study was to establish a simple and reproducible antegrade perfusion
method for isolating single viable mouse heart cells and to determine the standard practical …

Primary cardiomyocytes are invaluable for understanding postnatal heart development.
However, a universal method to obtain freshly purified cardiomyocytes without using …

Stem cell–derived cardiomyocytes (CMs) hold great hopes for myocardium regeneration
because of their ability to produce functional cardiac cells in large quantities. They also hold …

In the adult mammalian heart, no data have yet shown the existence of cardiomyocyte-
differentiable stem cells that can be used to practically repair the injured myocardium …