Toward normalization of the tumor microenvironment for cancer therapy
J Zheng, P Gao - Integrative cancer therapies, 2019 - journals.sagepub.com
The tumor microenvironment (TME) is a complex ecosystem, including blood vessels,
immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on. The TME …
immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on. The TME …
Inflammatory bowel disease and long-term risk of cancer: a prospective cohort study among half a million adults in UK Biobank
Background This study aims to examine the prospective association of inflammatory bowel
disease (IBD) with long-term risk of overall, site-specific cancer and cancer-specific mortality …
disease (IBD) with long-term risk of overall, site-specific cancer and cancer-specific mortality …
PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancer
D Wan, S Wang, Z Xu, X Zan, F Liu… - Clinical and …, 2022 - Wiley Online Library
Background Emerging studies have proved that colonic inflammation caused by refractory
inflammatory bowel disease (IBD) can initiate the colitis‐associated cancer (CAC), but the …
inflammatory bowel disease (IBD) can initiate the colitis‐associated cancer (CAC), but the …
Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage …
G Cui, Z Wang, H Liu, Z Pang - Frontiers in Immunology, 2022 - frontiersin.org
The majority of colorectal cancers (CRCs) are thought to arise from precancerous
adenomas. Upon exposure to diverse microenvironmental factors, precancerous stem cells …
adenomas. Upon exposure to diverse microenvironmental factors, precancerous stem cells …
Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities
Polyphenols from persimmon (Diospyros kaki) have demonstrated radical-scavenging and
antiinflammatory activities; however, little is known about the effects of persimmon phenolics …
antiinflammatory activities; however, little is known about the effects of persimmon phenolics …
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer
S Wagner, G Vlachogiannis, A De Haven Brandon… - Oncogene, 2019 - nature.com
Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi)
trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify …
trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify …
Role of the IL-33/ST2L axis in colorectal cancer progression
M Akimoto, K Takenaga - Cellular immunology, 2019 - Elsevier
Abstract Interleukin-33 (IL-33) has been identified as a natural ligand of ST2L. IL-33
primarily acts as a key regulator of Th2 responses through binding to ST2L, which is …
primarily acts as a key regulator of Th2 responses through binding to ST2L, which is …
The NLRP3 inflammasome: a therapeutic target for inflammation-associated cancers
M Gouravani, N Khalili, S Razi… - Expert Review of …, 2020 - Taylor & Francis
Introduction: Inflammasomes are large multimeric intracellular complexes that are capable of
maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18, in response to …
maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18, in response to …
Vitamin D and myofibroblasts in fibrosis and cancer: At cross-purposes with TGF-β/SMAD signaling
S Shany, INA Sigal-Batikoff, S Lamprecht - Anticancer research, 2016 - ar.iiarjournals.org
The multifaceted involvement of the active vitamin D metabolite 1, 25-dihydroxyvitamin D3
(henceforth referred to by the synonyms 1, 25 (OH) 2D3, calcitriol or vitamin D) in blunting …
(henceforth referred to by the synonyms 1, 25 (OH) 2D3, calcitriol or vitamin D) in blunting …
[HTML][HTML] Possible role of nutrition in the prevention of inflammatory bowel disease–related colorectal cancer: A focus on human studies
M Cassotta, D Cianciosi, R De Giuseppe… - Nutrition, 2023 - Elsevier
Patients with inflammatory bowel disease (IBD) are at substantially high risk for colorectal
cancer (CRC). IBD-associated CRC accounts for roughly 10% to 15% of the annual mortality …
cancer (CRC). IBD-associated CRC accounts for roughly 10% to 15% of the annual mortality …