The tumor microenvironment (TME) is a complex ecosystem, including blood vessels,
immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on. The TME …

Background This study aims to examine the prospective association of inflammatory bowel
disease (IBD) with long-term risk of overall, site-specific cancer and cancer-specific mortality …

Background Emerging studies have proved that colonic inflammation caused by refractory
inflammatory bowel disease (IBD) can initiate the colitis‐associated cancer (CAC), but the …

The majority of colorectal cancers (CRCs) are thought to arise from precancerous
adenomas. Upon exposure to diverse microenvironmental factors, precancerous stem cells …

Polyphenols from persimmon (Diospyros kaki) have demonstrated radical-scavenging and
antiinflammatory activities; however, little is known about the effects of persimmon phenolics …

Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi)
trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify …

Abstract Interleukin-33 (IL-33) has been identified as a natural ligand of ST2L. IL-33
primarily acts as a key regulator of Th2 responses through binding to ST2L, which is …

Introduction: Inflammasomes are large multimeric intracellular complexes that are capable of
maturation and secretion of pro-inflammatory cytokines, IL-1β and IL-18, in response to …

The multifaceted involvement of the active vitamin D metabolite 1, 25-dihydroxyvitamin D3
(henceforth referred to by the synonyms 1, 25 (OH) 2D3, calcitriol or vitamin D) in blunting …

Patients with inflammatory bowel disease (IBD) are at substantially high risk for colorectal
cancer (CRC). IBD-associated CRC accounts for roughly 10% to 15% of the annual mortality …