Hyaluronic a cid–doxorubicin nanoparticles for targeted treatment of colorectal cancer

DC Pan, V Krishnan, AK Salinas, J Kim… - Bioengineering & …, 2021 - Wiley Online Library
Colorectal cancer, common in both men and women, occurs when tumors form in the linings
of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and …

[HTML][HTML] Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

M Ohkuro, JD Kim, Y Kuboi, Y Hayashi… - Nature …, 2018 - nature.com
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a
chronic intestinal inflammatory condition initiated by integrins-mediated leukocyte adhesion …

[HTML][HTML] Deficiency in STAT1 signaling predisposes gut inflammation and prompts colorectal cancer development

S Leon-Cabrera, A Vázquez-Sandoval… - Cancers, 2018 - mdpi.com
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase
(JAK/STAT) signaling pathway that controls critical events in intestinal immune function …

Dysplasia and cancer in inflammatory bowel disease

LC Huang, A Merchea - Surgical Clinics, 2017 - surgical.theclinics.com
Inflammatory bowel disease (IBD) is associated with an increased risk of developing
dysplasia and cancer. 1–3 Dysplasia and colitis-associated cancer (CAC) develop via a …

miR-29a-5p/STAT3 positive feedback loop regulates TETs in colitis-associated colorectal cancer

A Wang, S Deng, X Chen, C Yu, Q Du… - Inflammatory bowel …, 2020 - academic.oup.com
Abstract Background Interleukin (IL)-6/signal transducers and activators of transcription 3
(STAT3) signaling plays an important role in the development of colitis-associated colorectal …

[HTML][HTML] Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice

J Rocha, R Direito, A Lima, J Mota, M Gonçalves… - Biomedicine & …, 2019 - Elsevier
Purpose Little is known about the pharmacological effects of the phenolic compounds of
Pennyroyal (Mentha pulegium). This Mediterranean aromatic plant, used as a gastronomic …

[HTML][HTML] Inula viscosa phenolic extract suppresses colon cancer cell proliferation and ulcerative colitis by modulating oxidative stress biomarkers

N Kheyar, Y Bellik, AT Serra, F Kheyar, F Bedjou - BioTechnologia, 2022 - ncbi.nlm.nih.gov
Inula viscosa is a perennial herbaceous plant native to the Mediterranean Basin, which is
used topically for the treatment of various diseases in folk medicine. This study aimed to …

Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium–specific Deletion of Klf4

VW Yang, Y Liu, J Kim, KR Shroyer… - Molecular Cancer …, 2019 - AACR
Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, regulates homeostasis of the
intestinal epithelium. Previously, it was reported that KLF4 functions as a tumor suppressor …

[HTML][HTML] Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas

WR Lin, JM Chiang, SN Lim, MY Su, TH Chen… - …, 2019 - thelancet.com
Background Energy metabolism in carcinogenesis is poorly understood. It is widely
accepted the majority of colorectal cancers (CRCs) arise from adenomatous polyps (APs) …

[HTML][HTML] NF-kappa B expression in resected specimen of colonic cancer is higher compared to its expression in inflammatory bowel diseases and polyps

L Berkovich, M Gerber, A Katzav, D Kidron, S Avital - Scientific Reports, 2022 - nature.com
NF-Kappa B has a significant role in inflammatory processes as well as in colorectal cancer.
The aim of this study was to compare the expression of NF-kappa B in colonic …