[HTML][HTML] Tight junction proteins and signaling pathways in cancer and inflammation: a functional crosstalk
The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …
[HTML][HTML] Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …
harbors a large and diverse microbial population collectively called the gut microbiome …
Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
[HTML][HTML] Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical …
A Deodhar, PJ Mease, IB McInnes, X Baraliakos… - Arthritis research & …, 2019 - Springer
Background Secukinumab, a fully human immunoglobulin G1-kappa monoclonal antibody
that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in the …
that directly inhibits interleukin (IL)-17A, has been shown to have robust efficacy in the …
[HTML][HTML] Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease
CE Fogarty, A Bergmann - Cell Death & Differentiation, 2017 - nature.com
Apoptosis is a carefully orchestrated and tightly controlled form of cell death, conserved
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …
across metazoans. As the executioners of apoptotic cell death, cysteine-dependent …
[HTML][HTML] MicroRNA biomarkers in IBD—differential diagnosis and prediction of colitis-associated cancer
Inflammatory bowel disease (IBD) includes Crohn's disease (CD) and ulcerative colitis (UC).
These are chronic autoimmune diseases of unknown etiology affecting the gastrointestinal …
These are chronic autoimmune diseases of unknown etiology affecting the gastrointestinal …
[HTML][HTML] Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing
V Butin-Israeli, TM Bui, HL Wiesolek… - The Journal of …, 2019 - Am Soc Clin Investig
Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated
with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely …
with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely …
[HTML][HTML] Emodin inhibits inflammation, carcinogenesis, and cancer progression in the AOM/DSS model of colitis-associated intestinal tumorigenesis
Y Zhang, W Pu, M Bousquenaud, S Cattin… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is one of the most common cancer worldwide. Chronic
inflammation contributes to CRC development and progression. Emodin, is a natural …
inflammation contributes to CRC development and progression. Emodin, is a natural …
Colon cancer: inflammation-associated cancer
S Shawki, J Ashburn, SA Signs… - Surgical Oncology …, 2018 - surgonc.theclinics.com
Although colitis-associated cancer constitutes less than 2% of all colon cancers, 1 the
challenges associated with this type of this cancer have implications that relate to many …
challenges associated with this type of this cancer have implications that relate to many …
[HTML][HTML] The role of the immune system in IBD-associated colorectal cancer: from pro to anti-tumorigenic mechanisms
S Frigerio, DA Lartey, GR D'haens… - International journal of …, 2021 - mdpi.com
Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal
cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal …
cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal …