Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …

Overweight and obesity result from an imbalance between caloric intake and energy
expenditure, including expenditure from spontaneous physical activity (SPA). Changes in …

Energy expenditure and energy intake need to be balanced to maintain proper energy
homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the …

The study of energy expenditure (EE) has deep roots in understanding aging and lifespan in
all species. In humans, total EE decreases substantially in advanced age resulting from …

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing
number of individuals in both the developed and developing worlds. Both are associated …

The hypothalamic neuropeptides orexin A and B (hypocretin 1 and 2) are important
homeostatic mediators of central control of energy metabolism and maintenance of …

The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous
physical activity (SPA), as lesion or stimulation of this region alters these behaviors …

According to L avoisier,'Life is combustion'. But to what extent humans adapt to changes in
food intake through adaptive thermogenesis–by turning down the rate of heat production …