ICU-acquired infections in immunocompromised patients

L Kreitmann, J Helms, I Martin-Loeches, J Salluh… - Intensive Care …, 2024 - Springer
Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …

Dissecting mechanisms of fecal microbiota transplantation efficacy in disease

CM Andary, KF Al, JA Chmiel, S Gibbons… - Trends in Molecular …, 2024 - cell.com
Fecal microbiota transplantation (FMT) has emerged as an alternative or adjunct
experimental therapy for microbiome-associated diseases following its success in the …

Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes

Y Fu, Q Dou, K Smalla, Y Wang, TA Johnson… - Mlife, 2023 - Wiley Online Library
The emergence and rapid spread of antimicrobial resistance is of global public health
concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that …

[HTML][HTML] Long-term beneficial effect of faecal microbiota transplantation on colonisation of multidrug-resistant bacteria and resistome abundance in patients with …

S Nooij, KEW Vendrik, RD Zwittink, QR Ducarmon… - Genome Medicine, 2024 - Springer
Background Multidrug-resistant (MDR) bacteria are a growing global threat, especially in
healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention …

[HTML][HTML] Boosting Fitness Costs Associated with Antibiotic Resistance in the Gut: On the Way to Biorestoration of Susceptible Populations

F Baquero, J Rodríguez-Beltrán, TM Coque… - Biomolecules, 2024 - mdpi.com
The acquisition and expression of antibiotic resistance implies changes in bacterial cell
physiology, imposing fitness costs. Many human opportunistic pathogenic bacteria, such as …

Deciphering the gastrointestinal carriage of Klebsiella pneumoniae

AS Bray, MA Zafar - Infection and Immunity, 2024 - Am Soc Microbiol
Bacterial infections pose a significant global health threat, accounting for an estimated 7.7
million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably …

[HTML][HTML] Decolonization and Pathogen Reduction Approaches to Prevent Antimicrobial Resistance and Healthcare-Associated Infections

MR Mangalea, AL Halpin, M Haile… - Emerging Infectious …, 2024 - ncbi.nlm.nih.gov
Antimicrobial resistance in healthcare-associated bacterial pathogens and the infections
they cause are major public health threats affecting nearly all healthcare facilities …

[HTML][HTML] Bacterial diversity and specific taxa are associated with decolonization of carbapenemase-producing enterobacterales after fecal microbiota transplantation

B Davido, AR Watson, P de Truchis, G Galazzo… - Journal of Infection, 2024 - Elsevier
Objectives We evaluated the effect of fecal microbiota transplantation (FMT) on the
clearance of carbapenemase-producing Enterobacterales (CPE) carriage. Methods We …

Escape Velocity—the Launch of Microbiome Therapies

BJ Kelly, JH Kwon… - The Journal of Infectious …, 2024 - academic.oup.com
Abstract Food and Drug Administration approval of the first microbiome therapies represents
a true expansion the treatment paradigm for Clostridioides difficile but raises new questions …

[HTML][HTML] Selection versus transmission: Quantitative and organismic biology in antibiotic resistance

F Baquero, AE Pérez-Cobas, S Aracil-Gisbert… - Infection, Genetics and …, 2024 - Elsevier
We aimed to determine the importance of selection (mostly dependent on the anthropogenic
use of antimicrobials) and transmission (mostly dependent on hygiene and sanitation) as …