ICU-acquired infections in immunocompromised patients
Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease
Fecal microbiota transplantation (FMT) has emerged as an alternative or adjunct
experimental therapy for microbiome-associated diseases following its success in the …
experimental therapy for microbiome-associated diseases following its success in the …
Gut microbiota research nexus: One Health relationship between human, animal, and environmental resistomes
Y Fu, Q Dou, K Smalla, Y Wang, TA Johnson… - Mlife, 2023 - Wiley Online Library
The emergence and rapid spread of antimicrobial resistance is of global public health
concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that …
concern. The gut microbiota harboring diverse commensal and opportunistic bacteria that …
[HTML][HTML] Long-term beneficial effect of faecal microbiota transplantation on colonisation of multidrug-resistant bacteria and resistome abundance in patients with …
S Nooij, KEW Vendrik, RD Zwittink, QR Ducarmon… - Genome Medicine, 2024 - Springer
Background Multidrug-resistant (MDR) bacteria are a growing global threat, especially in
healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention …
healthcare facilities. Faecal microbiota transplantation (FMT) is an effective prevention …
[HTML][HTML] Boosting Fitness Costs Associated with Antibiotic Resistance in the Gut: On the Way to Biorestoration of Susceptible Populations
The acquisition and expression of antibiotic resistance implies changes in bacterial cell
physiology, imposing fitness costs. Many human opportunistic pathogenic bacteria, such as …
physiology, imposing fitness costs. Many human opportunistic pathogenic bacteria, such as …
Deciphering the gastrointestinal carriage of Klebsiella pneumoniae
AS Bray, MA Zafar - Infection and Immunity, 2024 - Am Soc Microbiol
Bacterial infections pose a significant global health threat, accounting for an estimated 7.7
million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably …
million deaths. Hospital outbreaks driven by multi-drug-resistant pathogens, notably …
[HTML][HTML] Decolonization and Pathogen Reduction Approaches to Prevent Antimicrobial Resistance and Healthcare-Associated Infections
MR Mangalea, AL Halpin, M Haile… - Emerging Infectious …, 2024 - ncbi.nlm.nih.gov
Antimicrobial resistance in healthcare-associated bacterial pathogens and the infections
they cause are major public health threats affecting nearly all healthcare facilities …
they cause are major public health threats affecting nearly all healthcare facilities …
[HTML][HTML] Bacterial diversity and specific taxa are associated with decolonization of carbapenemase-producing enterobacterales after fecal microbiota transplantation
Objectives We evaluated the effect of fecal microbiota transplantation (FMT) on the
clearance of carbapenemase-producing Enterobacterales (CPE) carriage. Methods We …
clearance of carbapenemase-producing Enterobacterales (CPE) carriage. Methods We …
Escape Velocity—the Launch of Microbiome Therapies
BJ Kelly, JH Kwon… - The Journal of Infectious …, 2024 - academic.oup.com
Abstract Food and Drug Administration approval of the first microbiome therapies represents
a true expansion the treatment paradigm for Clostridioides difficile but raises new questions …
a true expansion the treatment paradigm for Clostridioides difficile but raises new questions …
[HTML][HTML] Selection versus transmission: Quantitative and organismic biology in antibiotic resistance
We aimed to determine the importance of selection (mostly dependent on the anthropogenic
use of antimicrobials) and transmission (mostly dependent on hygiene and sanitation) as …
use of antimicrobials) and transmission (mostly dependent on hygiene and sanitation) as …