The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

Several recent studies have identified nuclear factor-κB as a key modulator in driving
inflammation to cancers. Besides this transcription factor, essential in regulating …

As part of ongoing research on cancer chemopreventive agents from botanical dietary
supplements, Garcinia mangostana L.(commonly known as mangosteen) was selected for …

Difference in the metabolism of normal and cancer cells inspires to search for new, more
specific and less toxic therapies than those currently used. The development of tumors is …

Inducible nitric oxide synthase (iNOS) is one of three key enzymes generating nitric oxide
(NO) from the amino acid l-arginine. iNOS-derived NO plays an important role in numerous …

Nitric oxide (NO) is a pleiotropic molecule critical to a number of physiological and
pathological processes. The last decade has witnessed major advances in dissecting NO …

The search for effective methods of cancer treatment and prevention has been a continuous
effort since the disease was discovered. Recently, there has been increasing interest in …

This review gives a comprehensive overview of cancer development and links it to the
current understanding of tumorigenesis and malignant progression in colorectal cancer. The …

Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and
non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant …

Colorectal cancer (CRC) is the one of the leading causes of cancer-related deaths in the
world. CRC is responsible for more than 600,000 deaths annually and incidence rates are …