Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

The selective removal of misfolded, aggregated, or aberrantly overexpressed protein plays
an essential role in maintaining protein-dominated biological processes. In parallel, the …

Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several
challenges remain before this approach can offer broad clinical translation of mRNA …

Small interfering RNA (siRNA) holds immense promise for suppressing gene expression
and treating various life‐threatening diseases, including cancer. However, efficient delivery …

Catalytic DNA circuits represent a versatile toolbox for tracking intracellular biomarkers yet
are constrained with low anti-interference capacity originating from their severe off-site …

Understanding the exocytosis of nanoparticles (NPs) from cells is valuable because it
informs design rules of NPs that support desirable cellular retention for nanomedicine …

Drug discovery and development has experienced an incredible paradigm shift in the past
two decades. What once was considered a predominant R&D landscape of small molecules …

Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by
cells of various origins. They contain different biological cargoes, protecting them from …

Oligonucleotide-based therapies are a promising approach for treating a wide range of hard-
to-treat diseases, particularly genetic and rare diseases. These therapies involve the use of …

Over the past few decades, the complexity of molecular entities being advanced for
therapeutic purposes has continued to evolve. A main propellent fueling innovation is the …