Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

This introductory article should be viewed as a prologue to the Free Radical Biology &
Medicine Special Issue devoted to the important topic of Oxidatively Damaged DNA and its …

Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …

Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …

Genomic and mitochondrial DNA molecules are exposed continuously for a damaging
activity of chemical, physical, and internal genotoxicants. When DNA repair machinery is not …

The accumulation of somatic DNA mutations over time is a hallmark of aging in many
dividing and nondividing cells but has not been studied in postmitotic human …

The six major mammalian DNA repair pathways were discovered as independent
processes, each dedicated to remove specific types of lesions, but the past two decades …

UV-DDB, consisting of subunits DDB1 and DDB2, recognizes UV-induced photoproducts
during global genome nucleotide excision repair (GG-NER). We recently demonstrated a …

Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …

The ribosome is a complex ribonucleoprotein-based molecular machine that orchestrates
protein synthesis in the cell. Both ribosomal RNA and ribosomal proteins can be chemically …