Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

The epithelial–mesenchymal transition (EMT) provides an outstanding example of cellular
plasticity during embryonic development and cancer progression. During EMT in embryonic …

Immune checkpoint blockage has been considered a breakthrough in cancer treatment,
achieving encouraging anti-tumor effects in some advanced solid malignancies. However …

Background The macrophage, one of the several key immune cell types, is believed to be
involved in tumorigenesis. However, the mechanism of macrophages promoting tumor …

Epithelial–mesenchymal transition (EMT) has been implicated in various aspects of tumor
development, including tumor invasion and metastasis, cancer stemness, and therapy …

Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On
the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth …

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

The tumor microenvironment (TME) consists of various components including cancer cells,
tumor vessels, cancer‐associated fibroblasts (CAFs), and inflammatory cells. These …

The review aims to comprehensively present the impact of exposure to endocrine disruptors
(EDs) in relation to the clinical manifestation of obesity and related diseases, including …

Tumor cells, which undergo Epithelial-mesenchymal transition (EMT) acquire increased
capacities of proliferation, invasion and have the ability to generate metastases by escaping …