This paper describes the structure-based design of a preliminary drug candidate against
COVID-19 using free software and publicly available X-ray crystallographic structures. The …

A deaminative reductive coupling of amino acid pyridinium salts with aryl bromides has
been developed to enable efficient synthesis of noncanonical amino acids and …

The primary aim of this review article is to highlight current exciting and future looking areas
of research in peptide science as applied to the discovery and development of novel …

Macrocyclic peptides open new opportunities to target intracellular protein–protein
interactions (PPIs) that are often considered nondruggable by traditional small molecules …

This paper presents the design and study of a first-in-class cyclic peptide inhibitor against
the SARS-CoV-2 main protease (M pro). The cyclic peptide inhibitor is designed to mimic the …

Macrocyclic α-helical peptides have emerged as a compelling new therapeutic modality to
tackle targets confined to the intracellular compartment. Within the scope of hydrocarbon …

Although endogenous peptides and peptide-based therapeutics are both highly relevant to
human health, there are few approaches for sensitive biosensing of this class of molecules …

There has been an increased interest in and activity for the use of peptide therapeutics to
treat a variety of human diseases. The number of peptide drugs entering clinical …

Macrocyclic peptides show promise in targeting high-value therapeutically relevant binding
sites due to their high affinity and specificity. However, their clinical application is often …

Antimicrobial peptides (AMPs) are generally small cationic amphipathic peptides, which are
thought to be ideal antineoplastic agents, owing to their favorable selectivity to cancer cells …