The “old” and the “new” antibiotics for MDR gram-negative pathogens: for whom, when, and how
The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …
significant challenges in the treatment of healthcare associated infections. An important …
Nanoparticle-based local antimicrobial drug delivery
Despite the wide success of antibiotics in modern medicine, the treatment of bacterial
infections still faces critical challenges, especially due to the rapid emergence of antibiotic …
infections still faces critical challenges, especially due to the rapid emergence of antibiotic …
Combination therapy for treatment of infections with gram-negative bacteria
PD Tamma, SE Cosgrove… - Clinical microbiology …, 2012 - Am Soc Microbiol
Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …
employed in many health care facilities, especially for certain subgroups of patients …
Anti-virulence strategies to combat bacteria-mediated disease
DA Rasko, V Sperandio - Nature reviews Drug discovery, 2010 - nature.com
Antibiotic resistance is one of the greatest challenges of the twenty-first century. However,
the increasing understanding of bacterial pathogenesis and intercellular communication has …
the increasing understanding of bacterial pathogenesis and intercellular communication has …
Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes
Rates of antibiotic resistance in Pseudomonas aeruginosa are increasing worldwide. The
multidrug-resistant (MDR) phenotype in P. aeruginosa could be mediated by several …
multidrug-resistant (MDR) phenotype in P. aeruginosa could be mediated by several …
Cellular nanosponges for biological neutralization
Biological neutralization represents a general strategy that deploys therapeutic agents to
bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent …
bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent …
Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy
Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …
Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis
M Paul, S Grozinsky‐Glasberg… - Cochrane Database …, 2006 - cochranelibrary.com
Background Optimal antibiotic treatment for sepsis is imperative. Combining a beta‐lactam
antibiotic with an aminoglycoside antibiotic may have certain advantages over beta‐lactam …
antibiotic with an aminoglycoside antibiotic may have certain advantages over beta‐lactam …
[HTML][HTML] Appropriate antimicrobial therapy in the era of multidrug-resistant human pathogens
The past decade has brought a significant rise in antimicrobial resistance, and the ESKAPE
pathogens have become a significant threat to public health. Three epidemiological features …
pathogens have become a significant threat to public health. Three epidemiological features …
Pseudomonas aeruginosa: патогенность, патогенез и патология
АВ Лазарева, ИВ Чеботарь… - Клиническая …, 2015 - cyberleninka.ru
Синегнойная палочка Pseudomonas aeruginosa входит в число наиболее актуальных
возбудителей оппортунистических инфекций. Настоящий обзор литературы содержит …
возбудителей оппортунистических инфекций. Настоящий обзор литературы содержит …