The “old” and the “new” antibiotics for MDR gram-negative pathogens: for whom, when, and how

I Karaiskos, S Lagou, K Pontikis, V Rapti… - Frontiers in public …, 2019 - frontiersin.org
The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …

Nanoparticle-based local antimicrobial drug delivery

W Gao, Y Chen, Y Zhang, Q Zhang, L Zhang - Advanced drug delivery …, 2018 - Elsevier
Despite the wide success of antibiotics in modern medicine, the treatment of bacterial
infections still faces critical challenges, especially due to the rapid emergence of antibiotic …

Combination therapy for treatment of infections with gram-negative bacteria

PD Tamma, SE Cosgrove… - Clinical microbiology …, 2012 - Am Soc Microbiol
Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

Anti-virulence strategies to combat bacteria-mediated disease

DA Rasko, V Sperandio - Nature reviews Drug discovery, 2010 - nature.com
Antibiotic resistance is one of the greatest challenges of the twenty-first century. However,
the increasing understanding of bacterial pathogenesis and intercellular communication has …

Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes

EB Hirsch, VH Tam - Expert review of pharmacoeconomics & …, 2010 - Taylor & Francis
Rates of antibiotic resistance in Pseudomonas aeruginosa are increasing worldwide. The
multidrug-resistant (MDR) phenotype in P. aeruginosa could be mediated by several …

Cellular nanosponges for biological neutralization

S Wang, D Wang, Y Duan, Z Zhou, W Gao… - Advanced …, 2022 - Wiley Online Library
Biological neutralization represents a general strategy that deploys therapeutic agents to
bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent …

Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii: resistance mechanisms and implications for therapy

AP Zavascki, CG Carvalhaes, RC Picao… - Expert review of anti …, 2010 - Taylor & Francis
Pseudomonas aeruginosa and Acinetobacter baumannii are major nosocomial pathogens
worldwide. Both are intrinsically resistant to many drugs and are able to become resistant to …

Beta lactam antibiotic monotherapy versus beta lactam‐aminoglycoside antibiotic combination therapy for sepsis

M Paul, S Grozinsky‐Glasberg… - Cochrane Database …, 2006 - cochranelibrary.com
Background Optimal antibiotic treatment for sepsis is imperative. Combining a beta‐lactam
antibiotic with an aminoglycoside antibiotic may have certain advantages over beta‐lactam …

[HTML][HTML] Appropriate antimicrobial therapy in the era of multidrug-resistant human pathogens

JM Pogue, KS Kaye, DA Cohen, D Marchaim - Clinical Microbiology and …, 2015 - Elsevier
The past decade has brought a significant rise in antimicrobial resistance, and the ESKAPE
pathogens have become a significant threat to public health. Three epidemiological features …

Pseudomonas aeruginosa: патогенность, патогенез и патология

АВ Лазарева, ИВ Чеботарь… - Клиническая …, 2015 - cyberleninka.ru
Синегнойная палочка Pseudomonas aeruginosa входит в число наиболее актуальных
возбудителей оппортунистических инфекций. Настоящий обзор литературы содержит …