In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Mucosal surfaces are a main entry point for pathogens and the principal sites of defense
against infection. Both bacteria and phage are associated with this mucus. Here we show …

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …

Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI)
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …

The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …

Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Highly viscoelastic and adhesive sputum has precluded efficient nanoparticle-based drug
and gene delivery to the lungs of patients with cystic fibrosis (CF). We sought to determine …

Although nanotechnology has been investigated during recent years to increase the
bioavailability and therapeutic effects of mucosal administrated drugs, numerous barriers …

Cystic fibrosis (CF) patients suffer from chronic bacterial lung infections that lead to death in
the majority of cases. The need to maintain lung function in these patients means that …