Background The protective effect of estrogen on the vasculature cannot be explained only
by its action through the receptors ERα and ERβ. G protein-coupled estrogen receptors …

Pulmonary hypertension (PH) is a disease of women (female-to-male ratio 4: 1), and is
associated with cardiac and skeletal muscle dysfunction. Herein, the activation of a new …

Documented male-female differences in the risk of cardiovascular and chronic kidney
diseases have been largely attributed to estrogens. The cardiovascular and renal protective …

The G protein–coupled estrogen receptor 1 (GPER1) mediates rapid estrogenic signaling.
We recently reported that activation of GPER1 in the renal medulla evokes endothelin-1 …

Cardiovascular (CV) and renal diseases are increasingly prevalent in the United States and
globally. CV-related mortality is the leading cause of death in the United States, while renal …

Purpose: Assessing cardiotoxicity as a result of breast cancer therapeutics is increasingly
important as breast cancer diagnoses are trending younger and overall survival is …

Chronic activation of the novel estrogen receptor GPR30 by its agonist G1 mitigates the
adverse effects of estrogen (E2) loss on cardiac structure and function. Using the …

As an agonist of the classical nuclear receptors, estrogen receptor‐α and‐β (NR3A1/2),
estrogen has been assumed to inhibit the development of cardiovascular disease in …

Background: The increased risk of post-menopausal women developing abnormalities of
heart function emphasises the requirement to understand the effect of declining oestrogen …

Aim An imbalance between antioxidant and pro-oxidant factors, with a predominance of the
latter, characterises oxidative stress and is indicative of a loss of vascular function. The …