The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

0 VER the past decade a clearer understand-ing has emerged regarding the diverse
structural, metabohc, and functional consequences of myocardial ischemia. Animal studies …

A multicellular ventricular fiber model was used to determine mechanisms of slowed
conduction and conduction failure during acute ischemia. We simulated the three major …

An experimental approach is described to quantitate inhomogeneity in extracellular K
concentration ([K+] out) in the presence of ischemia and to relate this inhomogeneity to the …

The heart is well known as a metabolic omnivore in that it is capable of consuming fatty
acids, glucose, ketone bodies, pyruvate, lactate, amino acids and even its own constituent …

We studied the individual and combined effects of extracellular acidosis and increases in
extracellular potassium on action potential characteristics and conduction in order to gain a …

Background The aim of this study was to test the hypothesis that acute myocardial ischaemia
increases QT dispersion measured from the 12-lead electrocardiogram. Methods …

The role of the ATP-sensitive K+ current (IK-ATP) and its contribution to electrophysiological
changes that occur during metabolic impairment in cardiac ventricular myocytes is still being …

Acute myocardial ischemia is one of the main causes of sudden cardiac death. The
mechanisms have been investigated primarily in experimental and computational studies …