Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells following
binding with the cell surface ACE2 receptors, thereby leading to coronavirus disease 2019 …

The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

Survivin is the smallest member of the inhibitor of apoptosis protein family, which has key
roles in regulating cell division and inhibiting apoptosis by blocking caspase activation …

Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …

Purpose Cancer-related mortality, a leading cause of death worldwide, is often the result of
metastatic disease recurrence. Anesthetic techniques have varying effects on innate and …

Vascular injury of esophageal and gastrointestinal mucosa caused by injurious and
ulcerogenic factors leads to the cessation of blood flow, ischemia, and hypoxia and tissue …

Cancer, the main cause of human deaths in the modern world is a group of diseases.
Anticancer drug discovery is a challenge for scientists because of involvement of multiple …

Abnormal glucose metabolism is central to neurodegeneration, and considerable evidence
suggests that abnormalities in key enzymes of the tricarboxylic acid (TCA) cycle underlie the …

Many metabolic alterations, including the Warburg effect, occur in cancer cells that influence
the tumor microenvironment, including switching to glycolysis from oxidative …