Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - science.org
INTRODUCTION In Alzheimer's disease (AD), the production of amyloid β (Aβ) oligomers
and downstream tau dysfunction are thought to cause neuronal damage, in particular a loss …

Amyloid b oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - ohsu.elsevierpure.com
Cerebral blood flow is reduced early in the onset of Alzheimer's disease (AD). Because most
of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of …

[PDF][PDF] Amyloid b oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - ohsu.edu
RESULTS: Both in humans developing AD and in the mouse model of AD, capillaries were
constricted specifically at pericyte locations, but arterioles and venules were unchanged in …

[HTML][HTML] Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo… - Science (New York …, 2019 - ncbi.nlm.nih.gov
Cerebral blood flow is reduced early in Alzheimer's disease (AD). Because most of the
vascular resistance within the brain is in capillaries, this could reflect dysfunction of …

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - cir.nii.ac.jp
抄録< jats: title> Pericytes put the squeeze on cognition</jats: title>< jats: p> Like a
computer, the brain needs a reliable source of power, which is provided as oxygen and …

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo… - … (New York, NY), 2019 - pubmed.ncbi.nlm.nih.gov
Cerebral blood flow is reduced early in the onset of Alzheimer's disease (AD). Because most
of the vascular resistance within the brain is in capillaries, this could reflect dysfunction of …

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - Science, 2019 - discovery.ucl.ac.uk
Cerebral blood flow is reduced early in Alzheimer's disease (AD). Because most of the
vascular resistance within the brain is in capillaries, this could reflect dysfunction of …

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

R Nortley, N Korte, P Izquierdo… - Science (New York …, 2019 - europepmc.org
Cerebral blood flow is reduced early in Alzheimer's disease (AD). Because most of the
vascular resistance within the brain is in capillaries, this could reflect dysfunction of …

[PDF][PDF] Amyloid b oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

R Nortley, N Korte, P Izquierdo, C Hirunpattarasilp… - molecularneurology.unich.it
RESULTS: Both in humans developing AD and in the mouse model of AD, capillaries were
constricted specifically at pericyte locations, but arterioles and venules were unchanged in …

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

R Nortley, N Korte, P Izquierdo… - Science (New York …, 2019 - europepmc.org
Cerebral blood flow is reduced early in Alzheimer's disease (AD). Because most of the
vascular resistance within the brain is in capillaries, this could reflect dysfunction of …