Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
SG Krimmer, N Bertoletti, Y Suzuki… - Proceedings of the …, 2023 - National Acad Sciences
The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
SG Krimmer, N Bertoletti, Y Suzuki, L Katic… - Proceedings of the …, 2023 - europepmc.org
Results To gain further insights into the physiological and oncogenic activation mechanism
of KIT, we pursued structural investigations of SCF-induced full-length KIT dimers and of …
of KIT, we pursued structural investigations of SCF-induced full-length KIT dimers and of …
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
SG Krimmer, N Bertoletti, Y Suzuki… - Proceedings of the …, 2023 - ui.adsabs.harvard.edu
Physiological activation of the receptor tyrosine kinase KIT requires SCF-induced KIT
dimerization and activation. Aberrant activation by somatic KIT mutations has been …
dimerization and activation. Aberrant activation by somatic KIT mutations has been …
[HTML][HTML] Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
SG Krimmer, N Bertoletti, Y Suzuki, L Katic… - Proceedings of the …, 2023 - ncbi.nlm.nih.gov
Results To gain further insights into the physiological and oncogenic activation mechanism
of KIT, we pursued structural investigations of SCF-induced full-length KIT dimers and of …
of KIT, we pursued structural investigations of SCF-induced full-length KIT dimers and of …
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention
SG Krimmer, N Bertoletti, Y Suzuki… - Proceedings of the …, 2023 - pubmed.ncbi.nlm.nih.gov
The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
SG Krimmer, N Bertoletti, Y Suzuki, L Katic… - Proceedings of the …, 2023 - europepmc.org
The receptor tyrosine kinase KIT and its ligand stem cell factor (SCF) are required for the
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …
development of hematopoietic stem cells, germ cells, and other cells. A variety of human …